2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lactate Dehydrogenase

Lactate Dehydrogenase

LDH

Lactate Dehydrogenase

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Lactate Dehydrogenase (LDH) is an enzyme that catalyzes the conversion of pyruvate, the end product of glycolysis, into lactate (and vice versa) with concomitant interconversion of NADH and NAD+. LDH is comprised of two major subunits, LDH-A and LDH-B, which can assemble into five different isoenzymes (LDH1, LDH2, LDH3, LDH4, and LDH5).

LDH-A is also known as the M subunit as it is predominantly found in skeletal muscle, and LDH-B is also known as the H subunit as it is predominantly found in the heart. LDH-A is a vital metabolic enzyme that is associated with cancer development, invasion, and metastasis. LDH-A is also the key player of the Warburg effect. LDH-A has been reported to correlate with clinicopathologic characteristics and survival outcome of multiple cancers. The inhibition of LDH-A has an anti-proliferative effect on primary breast tumors. LDH-B is a crucial glycolytic enzyme that catalyses conversion of lactate and NAD+ to pyruvate, NADH and H+. LDHB plays an important role in autophagy in cancer cells.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-131485
    3-Acetylpyridine adenine dinucleotide, 90%
    3-Acetylpyridine adenine dinucleotide, 90% is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 90% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite.
    3-Acetylpyridine adenine dinucleotide, 90%
  • HY-N2498
    Glomeratose A
    		Inhibitor 99.89%
    Glomeratose A is a lactate dehydrogenase inhibitor, isolated from Polygala tenuifolia.
    Glomeratose A
  • HY-147361
    LDCA
    		Inhibitor 99.18%
    LDCA is a dual-hit metabolic modulator and inhibits LDH-A enzyme activity to stimulate apoptosis in the malignant population. LDCA can be used for the research of oncogenic progression.
    LDCA
  • HY-156683
    CHK-336
    		Inhibitor 98.05%
    CHK-336 (Example 1) is an orally active LDHA inhibitor (IC50<1 nM) that inhibits lactate production in mouse hepatocytes. CHK-336 can be used in the study of hyperoxaluria.
    CHK-336
  • HY-N7393
    Isomalt
    		≥98.0%
    Isomalt (Palatinitol), a well-tolerated, non-toxic polyol and a protein-stabilizing excipient, stabilizes lactate dehydrogenase (LDH) moderately during freeze-drying, and performs better during storage. Isomalt is traditionally used as a sweetening agent in the food industry and as a tabletting excipient for pharmaceutical purposes.
    Isomalt
  • HY-N2177
    3-Dehydrotrametenolic acid
    		Inhibitor 99.86%
    3-​Dehydrotrametenolic acid, isolated from the sclerotium of Poria cocos, is a lactate dehydrogenase (LDH) inhibitor. 3-​Dehydrotrametenolic acid promotes adipocyte differentiation in vitro and acts as an insulin sensitizer in vivo. 3-​Dehydrotrametenolic acid induces apoptosis and has anticancer activity.
    3-Dehydrotrametenolic acid
  • HY-P2807F
    Lactate Dehydrogenase (LDH), Bovine Heart
    Lactate Dehydrogenase (LDH), Bovine Heart (LAD, LD, L-LDH, (S)-Lactate: NAD+ oxidoreductase) is a biological material or organic compound that can be used in life science research.
    Lactate Dehydrogenase (LDH), Bovine Heart
  • HY-P2807I
    L-Lactate Dehydrogenase, rabbit muscle
    L-Lactate Dehydrogenase, rabbit muscle is a biological material or organic compound that can be used in life science research.
    L-Lactate Dehydrogenase, rabbit muscle
  • HY-132606
    Nedosiran
    		Inhibitor
    Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran represents an impactful potential therapeutic for primary hyperoxaluria (PH) with end-stage renal disease (ESRD). Nedosiran is a GalNAc-dsRNA conjugate.
    Nedosiran
  • HY-115875
    LDHA-IN-5
    		Inhibitor
    LDHA-IN-5 is a novel, potent, dual GO/LDHA inhibitor for primary hyperoxaluria.
    LDHA-IN-5
  • HY-154865
    Anticancer agent 121
    		Inhibitor
    Anticancer agent 121, an inhibitor of human lactate dehydrogenase A enzyme (hLDHA), has good anticancer activities and can be used for anticancer research.
    Anticancer agent 121
  • HY-P2807D
    Lactate Dehydrogenase 3 (LDH-3), Human Erythrocytes
    Lactate Dehydrogenase 3 (LDH-3), Human Erythrocytes (LDH-3, LD3, LD-3, 2H2M) is a biological material or organic compound that can be used in life science research.
    Lactate Dehydrogenase 3 (LDH-3), Human Erythrocytes
  • HY-156442
    MEDS433
    		Inhibitor
    MEDS433 is a potent inhibitor of human dihydroorotate dehydrogenase (hDHODH) with an IC50 of 1.2 nM. MEDS433 exerts a potent antiviral activity against RSV-A and RSV-B in the one-digit nanomolar range. MEDS433 induces the expression of antiviral proteins encoded by interferon stimulated genes (ISGs) able to reduce RSV replication.
    MEDS433
  • HY-P2807G
    Lactate Dehydrogenase (LDH), Chicken Heart
    Lactate Dehydrogenase (LDH), Chicken Heart (LAD, LD, L-LDH, (S)-Lactate, LDH) is a biological material or organic compound that can be used in life science research.
    Lactate Dehydrogenase (LDH), Chicken Heart
  • HY-P2807J
    L-Lactate Dehydrogenase (L-LDH), pig muscle
    L-Lactate Dehydrogenase (L-LDH), pig muscle is an L-lactate dehydrogenase found in pig muscle, mainly present in anaerobic tissues (skeletal muscle, red blood cells). L-Lactate Dehydrogenase (L-LDH), pig muscle can interact with acidic liposomes at low pH, causing protein to adsorb onto the liposomes and inhibit enzyme activity. The IC50 values for L-Lactate Dehydrogenase (L-LDH), pig muscle are 0.05 μM for cardiolipin and 1.3 μM for phosphatidylserine liposomes.
    L-Lactate Dehydrogenase (L-LDH), pig muscle
  • HY-161279
    Antibiofilm agent-5
    		Inhibitor
    Antibiofilm agent-5 (compound 6c) is a multitargeting antibacterial agent with potent antibiofilm activity. Antibiofilm agent-5 could induce metabolic dysfunction by deactivating lactate dehydrogenase and promote the accumulation of reactive oxygen species to decrease the reduced glutathione and ultimately cause oxidative damage in bacteria. Antibiofilm agent-5 can be used for the research of refractory biofilm-intensified bacterial infections.
    Antibiofilm agent-5
  • HY-P2807C
    Lactate Dehydrogenase 2 (LDH-2), Human Erythrocytes
    Lactate Dehydrogenase 2 (LDH-2), Human Erythrocytes (LDH-2 (3H1M), LD2) is a biological material or organic compound that can be used in life science research.
    Lactate Dehydrogenase 2 (LDH-2), Human Erythrocytes
  • HY-131485A
    3-Acetylpyridine adenine dinucleotide, 95%
    		Inhibitor
    3-Acetylpyridine adenine dinucleotide, 95% (3-APAD, 95%)is an analog of nicotinamide adenine dinucleotide (NAD). 33-Acetylpyridine adenine dinucleotide, 95% collaboratively inhibits Lactate Dehydrogenase (LDH) with bisulfite.
    3-Acetylpyridine adenine dinucleotide, 95%
  • HY-169060
    LDHA-IN-8
    		Inhibitor
    LDHA-IN-8 (Compound 6) is a lactate dehydrogenase (LDHA) inhibitor. LDHA-IN-8 inhibits LDHA catalysis of pyruvate in a dose-dependent manner (EC50 value of 14.54 μM), reduces intracellular lactate levels, and increases intracellular reactive oxygen species (ROS) levels, thereby inhibiting the proliferation of pancreatic cancer cells and lung cancer cells. LDHA-IN-8 holds promise for research in the field of LDHA-related antitumor therapies.
    LDHA-IN-8
  • HY-W040073S
    Nifurtimox-d4
    		Inhibitor
    Nifurtimox-d4 is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).
    Nifurtimox-d<sub>4</sub>
Cat. No. Product Name / Synonyms Application Reactivity